Immune Health

Immune Health

What is ABB C1®?

The new gold standard in trained immunity

ABB C1® is a unique combination of mineral yeast and beta-glucan complex that enhances trained immunity through the power of synergy.

  • Modifies the cells of the innate immune system by stimulating their memory so that they will react better and more quickly to any threats.
  • Clinically proven to reduce the gap between innate and adaptive immunity, training the immune system to function at the highest level.
  • Combines highly functional postbiotic yeast beta-glucans, rich in both zinc and selenium.
  • Protects the integrity of the intestine from disruption that may be caused by pathogens or allergens.
  • Efficiently prevents multiple immunity-weakening impacts of a pathogen infection.
  • Simultaneously reinforces innate and adaptive immune defences.

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The ABB C1® difference

ABB C1® beta-glucan is a patent-pending, novel, high-complexity blend of two separate beta-glucans (β-1,3/1,6-glucan) from Saccharomyces cerevisiae. Studies show this unique complex can simultaneously activate multiple immune receptors, induce trained immunity, and limit pro-inflammatory mediators released in the innate immune response. 

The ABB C1® beta-glucan complex acts synergistically to yield a more robust trained innate immune response than other yeast-derived beta-glucans. 

ABB C1® beta-glucan complex also provides two other powerful supporting ingredients:

  • Selenium-rich postbiotic from S. cerevisiae. This is unique from other selenium ingredients because selenium is organically bound during a fermentation process and incorporated into the selenoproteins, allowing for high bioavailability with a low risk of toxicity.1,2
  • Zinc-rich postbiotic from S. cerevisiae. The zinc-rich postbiotic is covalently bound during manufacturing and has been shown to have superior absorption and retention over other salt forms of zinc. Additionally, a positive interaction between elemental zinc and its yeast carrier limits zinc’s reaction with other substances in the gut, reducing the chance of toxicity.3

Unlike other yeast-derived beta-glucan bioactives, ABB C1® provides three unique mechanisms of action that work synergistically to have a far more profound impact on the immune system.

  • The novel combination of two highly effective β-1,3/1,6-glucans from S. cerevisiae activates the innate immune system and stimulates trained immunity more effectively than competitors.
  • Selenium and zinc-rich postbiotics provide targeted nutrition to support critical immune cells and antibodies. Combined, these minerals have been shown to be more effective against respiratory infections.4 And most importantly, selenium plus beta-glucan improves the immune modulatory effects of beta-glucan.5
  • S. cerevisiae provides additional immune-modulating effects through its impact on the gut microbiome. It helps bind and neutralize pathogenic microbes, strengthens the gut lining, and promotes a healthy inflammatory response.6,7

What is trained immunity?

Trained immunity refers to the ability of the innate immune system to develop adaptive features, thus providing enhanced, longer-term protection against pathogenic reinfection from a second, unrelated exposure. It’s characterized by long-term epigenetic changes and metabolic reprogramming of immune cells and pathways. Both internal and external stimuli can trigger trained immunity.8,9,10

Trained immunity is a bridge between the innate and adaptive immune systems. It is activated immediately upon exposure to a pathogen, and its actions last between three to 12 months. Innate immune cells return to an inactivated state when the original pathogen is eliminated. Still, the trained innate system can respond faster and more robustly in future encounters with another pathogenic invasion. The trained immune response differs from an acquired immune response because it can be unrelated to the original pathogen.8,9,10

This emerging concept in immunology is supported by a growing body of research that suggests trained immunity plays a vital role in vaccine response and may be an important tool for preventing infectious diseases and protecting against allergens. It also holds hope as a potential therapeutic strategy to manage certain health conditions associated with immune system malfunction, such as cancer.8

Beta-glucan and trained immunity

It’s possible to induce trained immunity with various external stimuli. One that has been shown to be highly effective is beta-glucan, specifically β-1,3/1,6-glucan, derived from the cell wall of Saccharomyces cerevisiae, also known as baker’s yeast.11 Beta-glucans are derived from various sources, including oats, barley, yeast, mushrooms, and bacteria, but each source affords different health benefits. For example, beta-glucan from oats and barley provides metabolic benefits by reducing lipids and insulin resistance. 

Yeast beta-glucan acts as an immunomodulator, helping the immune system work more effectively by inducing trained immunity and modulating immune cells’ inflammatory and antimicrobial activity. Studies have shown that yeast-derived beta-glucan (β‐1,3/1,6‐glucan) can: 12,13,14,15

  • Strengthen the immune system, offering extra protection during periods of physical or emotional stress
  • Enhance immune system response to vaccination
  • Enhance the protection against allergies
  • Promote healthy inflammatory responses
  • Support respiratory health 

Application

The ABB C1® postbiotic offers a wide range of opportunity for integration into supplements designed to strengthen immune and allergy responses, or it can be used as a standalone supplement. This makes ABB Cl® ideal for manufacturers seeking to innovate and lead in the growing immune health market.

ABB C1® postbiotic sets itself apart with its versatility, owing to increased stability and consistency compared to traditional probiotics. Probiotics require meticulous handling to stay viable from production to consumption whereas ABB C1®'s postbiotic metabolites simplify the process as they don't need to be kept alive. This ease of use makes ABB C1® a practical choice for a wide range of integration opportunities.

The possibilities are endless - whatever you can imagine, we can support. 

Forms

ABB C1® is offered in various forms to suit diverse manufacturing needs:

       

Each format is designed for seamless integration into your product line-up, providing flexibility and convenience for your immune health innovations.

Research

Anti-Inflammatory Effects, Protection of Gut Barrier Integrity and Stimulation of Phagocytosis of Postbiotic Combination ABB C1

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Effect and Tolerability of a Nutritional Supplement Based on a Synergistic Combination of β-Glucans and Selenium- and Zinc-Enriched Saccharomyces cerevisiae (ABB C1®) in Volunteers Receiving the Influenza or the COVID-19 Vaccine

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Potent Induction of Trained Immunity by Saccharomyces cerevisiae beta-glucans

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BiomeNurturing Beyond Bacteria

Our products are available in multiple formats to meet the needs of consumers today.

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1. Kim, Y. Y. & Mahan, D. C. Comparative Effects of High Dietary Levels of Organic and Inorganic Selenium on Selenium Toxicity of Growing-Finishing Pigs. J. Anim. Sci. (2001). doi:10.2527/2001.794942x.
2. Payne, R. L. & Southern, L. L. Comparison of Inorganic and Organic Selenium Sources For Broilers. Poult. Sci. (2005). doi:10.1093/ps/84.6.898.
3. Gharekhani A, Azari Takami G, Tukmechi A, Afsharnasab M, Agh N. Effect of Dietary Supplementation With Zinc Enriched Yeast (Saccharomyces Cerevisiae) on the Immunity of Rainbow Trout (Oncorhynchus Mykiss). Iran J Vet Res. 2015 Summer;16(3):278-82.
4. Girodon, F. et al. Impact of Trace Elements and Vitamin Supplementation on Immunity and Infections in Institutionalized Elderly Patients: A Randomized Controlled Trial.  Intern. Med. (1999). doi:10.1001/archinte.159.7.748.
5. Vetvicka, V. & Vetvickova, J. Addition of Selenium Improves Immunomodulative Effects of Glucan.  Am. J. Med. Sci. 8,88-92(2016).
6. McFarland LV. Systematic Review and Meta-Analysis of Saccharomyces Boulardii in Adult Patients. World J Gastroenterol. 2010;16(18):2202-2222. doi:10.3748/wjg.v16.i18.2202.
7. Palma, M. L. et al. Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement? Applied Microbiology and Biotechnology (2015).
8. Dagenais A, Villalba-Guerrero C, Olivier M. Trained immunity: A “new” weapon in the fight against infectious diseases. Frontiers in Immunology. 2023 Mar 13;14:1147476.
9. Netea, M. G., Quintin, J. & van der Meer, J. W. Trained immunity: a memory for innate host defense. Cell Host Microbe 9, 355–361 (2011).
10. Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, O’Neill LA, Xavier RJ. Trained immunity: A program of innate immune memory in health and disease. Science. 2016 Apr 22;352(6284).
11. De Marco Castro E, Calder PC, Roche HM. β-1,3/1,6-Glucans and Immunity: State of the Art and Future Directions. Mol Nutr Food Res. 2021;65(1):e1901071. doi:10.1002/mnfr.201901071.
12. Krysten Fries-Craft and others, Dietary Yeast Beta 1,3/1,6 Glucan Supplemented to Adult Labrador Retrievers Alters Peripheral Blood Immune Cell Responses to Vaccination Challenge Without Affecting Protective Immunity. Journal of Animal Science, Volume 101, 2023, skad029, https://doi. org/10.1093/jas/skad029.
13. Talbott SM, Talbott JA, Talbott TL, Dingler E. (2013) ß-Glucan Supplementation, Allergy Symptoms and Quality of Life in Self-Described Ragweed Allergy Sufferers. Food Science & Nutrition 1:90-101. 
14. Stier H, Ebbeskotte V, Gruenwald J. Immune-Modulatory Effects of Dietary Yeast Beta-1,3/1,6-D-glucan. Nutr J. 2014 Apr 28;13:38. Doi: 10.1186/1475-2891-13-38.
15. Fuller R, Moore MV, Lewith G, Stuart BL, Ormiston RV, Fisk HL, Noakes PS, Calder PC. (2017) Yeast-Derived Beta 1,3/1,6 Glucan, Upper Respiratory Tract Infection and Innate Immunity in Older Adults. Nutrition 39-40:30-35.